Amentoflavone Attenuates Clostridium perfringens Gas Gangrene by Targeting Alpha-Toxin and Perfringolysin O
Clostridium perfringens (C.perfringens) type A strains are the main cause of gas gangrene in humans and animals.Treatment of this lethal disease is limited, and the prognosis is not good.Alpha-toxin (CPA) and perfringolysin O (PFO) secreted by C.perfringens play irreplaceable roles in cytotoxicity to host cells, persistence in host tissues, and Ani